I-SEARCH

Discover novel TCRs to expand your pipeline with high-quality candidates

A scientist or researcher looking through a microscope in a laboratory setting.

Unlock novel TCRs faster.

Developing new T-cell receptor (TCR) therapies demands speed, precision, and scale. Our I-SEARCH platform combines the core Tope-seq capability with single-cell TCR-seq technology to look for high-potential TCR from a wide variety of T cell sources using multiplexed sets of targets.

Generate a diverse portfolio of TCR candidates across multiple antigen targets—enabling informed prioritization before committing to a single path.

Simplified illustration of an assay and magnifying glass, indicating the search for new cellular therapies.

I-SEARCH Platform Capabilities

Simultaneously detect epitopes and TCRs

Validate novel epitope targets while discovering reactive TCRs in a single workflow. I-SEARCH functionally screens large candidate libraries and probes primary T cell populations using comprehensive, multiplexed target panels.

  • Combine Tope-seq with single-cell TCR-seq (scTCR-seq) to interrogate T cell populations using diverse minigene bait libraries

  • Link Tope-seq and scTCR-seq hits through our rapid cell prototyping system, enabling efficient validation of antigen–TCR pairs

Build custom libraries of high-value targets

Libraries are tailored to your biology and program goals.

  • Custom minigene libraries tiling pathogen genomes or cancer-associated genes

  • Synthetic minigenes encoding cancer mutations, expressed as neoepitopes across any HLA context

  • Unbiased patient-specific libraries, generated from fragmented DNA or RNA derived from patient tissues for personalized TCR discovery

Enable modular and
high-throughput discovery

Adapt I-SEARCH to your discovery strategy with a flexible, scalable system.

  • Customizable effector T cells paired with synthetic antigen-presenting cell (APC) libraries

  • Granzyme-based reporters within target cells enable Tope-seq identification of functionally active antigens

  • Activation markers on effector cells support isolation and single-cell TCR-seq of reactive TCRs

Maximize precious T cell samples

Get more insight from limited biological material.

  • Screen broadly from the start: directly apply patient-derived T cells to discovery campaigns spanning thousands of potential targets

  • No sample? No problem. Preserve limited primary material by recombinantly expressing TCR sequences in a TCR-T format for I-SEARCH discovery workflows

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